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Analysis of the wilms tumor suppressor gene WT1 in endometrial carcinoma
Author(s) -
Rackley Raymond,
Casey Graham,
Zhao XiaoIan,
Miller David W.,
Williams Bryan R. G.,
Coppes Max J.
Publication year - 1995
Publication title -
genes, chromosomes and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.754
H-Index - 119
eISSN - 1098-2264
pISSN - 1045-2257
DOI - 10.1002/gcc.2870140411
Subject(s) - wilms' tumor , tumor suppressor gene , suppressor , cancer research , malignancy , carcinoma , gene , endometrial cancer , biology , oncology , medicine , cancer , carcinogenesis , genetics
This study reports on the evaluation of the Wilms tumor suppressor gene WT1 in 14 endometrial carcinomas. Despite the fact that several endometrial carcinomas were shown to express WT1 , we were unable to demonstrate mutations in the MT1 zinc finger region, suggesting that WT1 does not play a prominent role in the etiology of this malignancy.