Premium
Massive cytogenetic heterogeneity in a pancreatic carcinoma: Fifty‐four karyotypically unrelated clones
Author(s) -
Gorunova Ludmila,
Johansson Bertil,
Dawiskiba Sigmund,
AndrénSandberg Åke,
Jin Yuesheng,
Mandahl Nils,
Heim Sverre,
Mitelman Felix
Publication year - 1995
Publication title -
genes, chromosomes and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.754
H-Index - 119
eISSN - 1098-2264
pISSN - 1045-2257
DOI - 10.1002/gcc.2870140404
Subject(s) - biology , chromosomal translocation , karyotype , clone (java method) , genetics , chromosome , ploidy , cytogenetics , gene duplication , somatic evolution in cancer , microbiology and biotechnology , gene
Chromosome analysis after short‐term culture revealed remarkable cytogenetic heterogeneity in a pancreatic carcinoma. The patient had no prior history of radio‐ or chemotherapy. A total of 54 aberrant, near‐diploid, karyotypically unrelated clones were identified, three of which displayed clonal evolution. The abnormalities were unbalanced in 30% of the clones. From one to eight karyotypic anomalies per clone were found. Numerical changes were rare, whereas structural aberrations were numerous and diverse and included deletions, duplication, insertions, inversions, translocations, ring formation, and telomeric associations. All chromosomes except No. 15 were involved in structural rearrangements, chromosomes 1, 6, 7, 8, 11, and 12 being the most frequently affected. A similarly massive cytogenetic polyclonality has never been reported previously. Although the spectrum of epithelial neoplasms characterized by karyotypically unrelated clones is increasing, the pathogenetic role of this type of cytogenetic intratumor heterogeneity remains unknown.