Predominance of normal karyotype in colorectal tumors from hereditary non‐polyposis colorectal cancer patients | Zendy

Muleris Martine | Zendy; Dutrillaux Anne Marie | Zendy; Olschwang Sylviane | Zendy; Salmon Remy Jacques | Zendy; Dutrillaux Bernard | Zendy

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Predominance of normal karyotype in colorectal tumors from hereditary non‐polyposis colorectal cancer patients

Author(s) -

Muleris Martine,

Dutrillaux Anne Marie,

Olschwang Sylviane,

Salmon Remy Jacques,

Dutrillaux Bernard

Publication year - 1995

Publication title -

genes, chromosomes and cancer

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.754

H-Index - 119

eISSN - 1098-2264

pISSN - 1045-2257

DOI - 10.1002/gcc.2870140312

Subject(s) - karyotype , colorectal cancer , medicine , oncology , cytogenetics , cancer , biology , pathology , gastroenterology , chromosome , genetics , gene

We report the cytogenetic study of 9 colorectal tumors arising in patients with hereditary non‐polyposis colorectal cancer (HNPCC). According to the cytogenetic classification of colorectal tumors previously proposed by us, 2 cases were of the trisomic type, 2 were of the monosomic type, and 5 had a normal karyotype. This represents a significant excess of tumors with normal karyotype in HNPCC tumors (56%) compared to sporadic cases (10/184 = 5%).

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