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Predominance of normal karyotype in colorectal tumors from hereditary non‐polyposis colorectal cancer patients
Author(s) -
Muleris Martine,
Dutrillaux Anne Marie,
Olschwang Sylviane,
Salmon Remy Jacques,
Dutrillaux Bernard
Publication year - 1995
Publication title -
genes, chromosomes and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.754
H-Index - 119
eISSN - 1098-2264
pISSN - 1045-2257
DOI - 10.1002/gcc.2870140312
Subject(s) - karyotype , colorectal cancer , medicine , oncology , cytogenetics , cancer , biology , pathology , gastroenterology , chromosome , genetics , gene
We report the cytogenetic study of 9 colorectal tumors arising in patients with hereditary non‐polyposis colorectal cancer (HNPCC). According to the cytogenetic classification of colorectal tumors previously proposed by us, 2 cases were of the trisomic type, 2 were of the monosomic type, and 5 had a normal karyotype. This represents a significant excess of tumors with normal karyotype in HNPCC tumors (56%) compared to sporadic cases (10/184 = 5%).