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Distinct Xp11.2 breakpoints in two renal cell carcinomas exhibiting X;autosome translocations
Author(s) -
Dijkhuizen T.,
van den Berg E.,
Wilbrink M.,
Weterman M.,
van Kessel A. Geurts,
Störkel S.,
Folkers R. P.,
Braam A.,
de Jong B.
Publication year - 1995
Publication title -
genes, chromosomes and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.754
H-Index - 119
eISSN - 1098-2264
pISSN - 1045-2257
DOI - 10.1002/gcc.2870140108
Subject(s) - breakpoint , chromosomal translocation , renal cell carcinoma , biology , cancer research , genetics , medicine , pathology , gene
Abstract Several human renal cell carcinomas with X;autosome translocations have been reported in recent years. The t(X;1)(p11.2;q21) appears to be a specific primary anomaly, suggesting that tumors with this translocation form a distinct subgroup of RCC. Here we report two new cases, one with a t(X;10)(p11.2;q23), the other with a t(X;1)(p11.2;p34). The common breakpoint in Xp11.2 suggests that they belong to the above‐mentioned subset of RCC. Using FISH in conjunction with X‐specific YAC clones, we demonstrate that the two new cases exhibited distinct breakpoints within Xp11.2.