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κ‐ and λ‐positive cells in centroblastic‐centrocytic lymphoma (follicular lymphoma) may share a secondary chromosome aberration: Reflections on early lymphoma development
Author(s) -
WeberMatthiesen Klaus,
Winkemann Martin,
Grote Werner,
Schlegelberger Brigitte
Publication year - 1995
Publication title -
genes, chromosomes and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.754
H-Index - 119
eISSN - 1098-2264
pISSN - 1045-2257
DOI - 10.1002/gcc.2870140105
Subject(s) - lymphoma , immunophenotyping , follicular lymphoma , pathology , interphase , cytogenetics , biology , trisomy , chromosome , medicine , immunology , flow cytometry , microbiology and biotechnology , gene , genetics
The technique of simultaneous fluorescence immunophenotyping and interphase cytogenetics (FICTION) was applied in four cases of centroblastic‐centrocytic (working formulation: follicular) lymphoma. Our aim in this study was to establish whether secondary chromosome aberrations known from a prior cytogenetic analysis were detectable in both κ‐ and λ‐expressing tumor cells from the same lymphoma patient. One of the cases did indeed contain κ‐ and λ‐positive tumor cells with trisomy 8. On the basis of our results, we reflect on the events that take place during early development of centroblastic‐centrocytic lymphoma.