Loss of Chromosome 17 loci in prostate cancer detected by polymerase chain reaction quantitation of allelic markers | Zendy

Brothman Arthur R. | Zendy; Steele Michael R. | Zendy; Williams Briana J. | Zendy; Jones Emma | Zendy; Odelberg Shan | Zendy; Albertsen Hans M. | Zendy; Jorde Lynn B. | Zendy; Rohr L. Ralph | Zendy; Stephenson Robert A. | Zendy

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Loss of Chromosome 17 loci in prostate cancer detected by polymerase chain reaction quantitation of allelic markers

Author(s) -

Brothman Arthur R.,

Steele Michael R.,

Williams Briana J.,

Jones Emma,

Odelberg Shan,

Albertsen Hans M.,

Jorde Lynn B.,

Rohr L. Ralph,

Stephenson Robert A.

Publication year - 1995

Publication title -

genes, chromosomes and cancer

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.754

H-Index - 119

eISSN - 1098-2264

pISSN - 1045-2257

DOI - 10.1002/gcc.2870130408

Subject(s) - loss of heterozygosity , locus (genetics) , polymerase chain reaction , microsatellite , biology , prostate cancer , allele , microbiology and biotechnology , gene , chromosome , prostate , genetics , cancer research , pathology , cancer , medicine

Using a polymerase chain reaction/microsatellite marker system, we demonstrated that 6 of 22 (27%) clinical stage B (early) primary prostate tumors showed loss of heterozygosity at one or more of five loci on chromosome 17. The sensitivity of this study was increased by use of a Phosphorlmager and statistical analysis of replicate tumor‐normal DNA pairs. Two patients showed tumor‐specific interstitial loss at a locus in close proximity to the familial breast cancer gene BRCAI. These findings suggest that genes on the proximal long arm of chromosome I7 play a pivotal role in the early development of at least a subset of prostatic tumors. © 1995 Wiley‐Liss, Inc.

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