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A new cytogenetic subgroup in uterine leiomyoma is characterized by a deletion of the long arm of chromosome 3
Author(s) -
Cin Paola Dal,
Moerman Philippe,
Deprest Jan,
Brosens Ivo,
Berghe Herman Van Den
Publication year - 1995
Publication title -
genes, chromosomes and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.754
H-Index - 119
eISSN - 1098-2264
pISSN - 1045-2257
DOI - 10.1002/gcc.2870130313
Subject(s) - uterine leiomyoma , leiomyoma , chromosome , biology , chromosome abnormality , cytogenetics , abnormality , karyotype , genetics , pathology , uterus , medicine , gene , psychiatry
Our cytogenetic findings in 175 uterine leiomyomas revealed 52 tumors with clonal chromosome abnormalities, eight of which did not belong to any well‐delineated cytogenetic abnormal subgroup. However, an interstitial deletion of the long arm of chromosome 3 was found, as the sole chromosome abnormality, in three cases. We believe that this involvement of 3q is significant enough to consider it as a new cytogenetic subgroup of uterine leiomyoma. © 1995 Wiley‐Liss, Inc.