Premium
dic(9; 20): A new recurrent chromosome abnormality in adult acute lymphoblastic leukemia
Author(s) -
Rieder Harald,
Schnittger Susanne,
Bodenstein Heinrich,
Schwonzen Martin,
Wörmann Bernhard,
Berkovic Dinko,
Ludwig WolfDieter,
Hoelzer Dieter,
Fonatsch Christa
Publication year - 1995
Publication title -
genes, chromosomes and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.754
H-Index - 119
eISSN - 1098-2264
pISSN - 1045-2257
DOI - 10.1002/gcc.2870130109
Subject(s) - dicentric chromosome , chromosomal translocation , chromosome , chromosome 22 , biology , fluorescence in situ hybridization , chromosome 15 , chromosome 21 , microbiology and biotechnology , chromosome 9 , karyotype , marker chromosome , chromosome 16 , chromosome 12 , genetics , chromosome abnormality , philadelphia chromosome , gene
Loss of chromosome 20 and rearrangement of the short arm of chromosome 9 were identified by banding analysis of three adult patients with acute lymphoblastic leukemia (ALL). The G‐banding pattern suggested and identical deletion of 9p, but, also, an unbalanced translocation with chromosome 20 was taken into consideration. Dual‐color chromosome painting with probes for chromosomes 9 and 20 revealed the presence of material from chromosome 20 at the short arm of the abnormal chromosome 9 in all three cases. Centromeric alpha‐satellite DNA of both chromosome 9 and chromosome 20 was demonstrated by fluorescence in situ hybridization and indicated the presence of a dicentric chromosome. The hybridization of a YAC clone of the short arm of chromosome 20 proved that the dicentric chromosome contained the short arm of chromosome 20, which had been suspected from the G‐banding pattern. Thus, the rearrangement was interpreted as dic(9; 20)(pl I;qi I . ? I). Because this was the sole chromosome abnormality in two patients, dic(9; 20) may be a primary chromosome aberration in ALL. In one case, a 9q + chromosome derived from a Philadelphia (Ph) translocation was involved in the formation of the dicentric chromosome. Immunophenotyping revealed CD 1o + B‐cell precursor ALL in all three cases. Whereas the two patients in whom dic(9; 20) was the sole cytogenetically detectable change are in continuous complete remission for 10 and 45 months, respectively, the Ph + patient relapsed with leukemia and died 8 months after diagnosis. © 1995 Wiley‐Liss, Inc.