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Characterization of add(I)(p36) in non‐hodgkin lymphomas by fluorescence in situ hybridization
Author(s) -
Bajalica Svetlana,
BrøndumNielsen Karen,
Sørensen AnneGrethe,
Pedersen Niels Tinggaard,
Kristoffersson Ulf,
Åkerman Måns,
Anderson Margareta,
Pisa Pavel,
Nordenskjöld Magnus
Publication year - 1995
Publication title -
genes, chromosomes and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.754
H-Index - 119
eISSN - 1098-2264
pISSN - 1045-2257
DOI - 10.1002/gcc.2870130106
Subject(s) - chromosomal translocation , fluorescence in situ hybridization , breakpoint , chromosome , follicular lymphoma , biology , fish <actinopterygii> , in situ hybridization , lymphoma , cytogenetics , follicular phase , microbiology and biotechnology , pathology , genetics , medicine , immunology , gene , gene expression , fishery
Chromosome rearrangements involving chromosome I, band p36, are among the most common aberrations in non‐Hodgkin lymphomas (NHL). We have studied nine cases of NHL with add(I)(p36) using fluorescence in situ hybridization (FISH) from a series of 205 cases. Five were follicular low‐grade NHL and four were follicular or diffuse high‐grade NHL. Three of the five cases with follicular low‐grade NHL did not contain the 14; 18 translocation. The extra material on the add(l)(p36) in these three cases was derived from chromosome segment 2q31‐qter; in one it was observed as a sole clonal rearrangement. In the two remaining cases, with t(14; 18), the add(l)(p36) consisted of material from chromosome arms 3q and 17q, respectively. In the four cases of high‐grade NHL, the material added on to I p36 was derived from chromosomes 6, 9, 17, and 19, respectively. Using a I p36‐specific probe, DIS94, we showed a deletion on the add(I) in one of the cases with low‐grade NHL, whereas no loss was observed in one of the cases with high‐grade NHL. Our study indicates that cytogenetically similar add(l)(p36) are found in both high‐ and low‐grade NHL, and the breakpoint on Ip36 as well as the origin of translocated material may vary. © 1995 Wiley‐Liss, Inc.