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Concurrent presence of inv(14)(q11q32) and t(4;11)(q21;q23) in Pre‐B Acute Lymphoblastic leukemia
Author(s) -
Chervinsky David S.,
Grossi Mauro,
Kakati Surabhi,
Block Annemarie W.,
Aplan Peter D.
Publication year - 1995
Publication title -
genes, chromosomes and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.754
H-Index - 119
eISSN - 1098-2264
pISSN - 1045-2257
DOI - 10.1002/gcc.2870120312
Subject(s) - lymphoblastic leukemia , medicine , cancer research , leukemia , microbiology and biotechnology , biology
The inv(14)(q11q32) is a non‐random chromosomal aberration which has been associated with a variety of T‐cell malignancies. We have studied a case of inv(14)(q11q32) that is unique in several respects. First, the inversion, which is expressed at the mRNA level, occurred in the context of a pre‐B acute lymphoblastic leukemia (ALL) as opposed to a T‐cell malignancy. Second, cloning and sequencing of the inversion revealed that it resulted from a fusion between an immunoglobulin heavy chain variable (V) segment and a T‐cell receptor delta diversity (D) segment. In addition, the patient had a second chromosomal abnormality at diagnosis, a t(4;11)(q21;q23) which disrupted the MLL gene. The fact that there were two distinct chromosomal abnormalities at diagnosis enabled us to address the question of leukemic clonal evolution during the course of this patient's disease. We present evidence suggesting that the t(4;11)(q21;q23) occurred first, with the inv(14)(q11q32) occurring as a second event.