Premium
New translocation t(2;13)(p12;q34) and rearrangement of the MLL gene in a childhood leukemia cell line
Author(s) -
Kees Ursula R.,
Campbell Lynda J.,
Ford Jette,
Willoughby Michael L. N.,
Peroni Susanne E.,
Ranford Pamela R.,
Garson O. Margaret
Publication year - 1995
Publication title -
genes, chromosomes and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.754
H-Index - 119
eISSN - 1098-2264
pISSN - 1045-2257
DOI - 10.1002/gcc.2870120307
Subject(s) - chromosomal translocation , immunophenotyping , leukemia , biology , gene rearrangement , phenotype , cancer research , karyotype , breakpoint , microbiology and biotechnology , bone marrow , gene , cell culture , abnormality , chromosome , genetics , immunology , medicine , flow cytometry , psychiatry
Here we report the case of a 7‐month‐old boy who presented with biphenotypic acute leukemia, but with leukemia cells of B‐cell phenotype present at the time of relapse. Two cell lines were derived from bone marrow specimens obtained at relapse, and immunophenotyping and analysis of antigen receptor gene configuration revealed concordance between the patient's leukemic cells and the cell lines. Cell line PER‐377 shows a new chromosomal abnormality, t(2;13)(p12;q34), a molecular rearrangement at chromosome band 11q23 in the absence of a cytogenetically detectable abnormality of this band, and deletion of the genes for IGK .