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Consistent presence of isochromosome 7q in hepatosplenic t γ/δ lymphoma: A new cytogenetic‐clinicopathologic entity
Author(s) -
Wang ChuanCheng,
Tien HweiFang,
Lin MingTseh,
Su IhJen,
Wang ChiuHwa,
Chuang SouMing,
Shen MingChing,
Liu ChenHui
Publication year - 1995
Publication title -
genes, chromosomes and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.754
H-Index - 119
eISSN - 1098-2264
pISSN - 1045-2257
DOI - 10.1002/gcc.2870120302
Subject(s) - isochromosome , lymphoma , pathology , bone marrow , trisomy 8 , peripheral t cell lymphoma , chromosomal abnormality , spleen , biology , abnormality , t cell lymphoma , medicine , cytogenetics , immunology , t cell , karyotype , chromosome , genetics , immune system , gene , psychiatry
Peripheral T‐cell lymphoma (PTL), which is characterized by hepatosplenic presentation and the γ/δ T‐cell receptor (TCR) phenotype on the malignant cells, is a rare but distinct subtype of non‐Hodgkin's lymphomas. Little is known about the chromosomal changes in these lymphomas. We report the cytogenetic analysis of three patients who had neoplastic proliferation of T γ/δ cells in the spleen, bone marrow, and liver, but not in lymph nodes or skin. Isochromosome 7q and trisomy 8 were observed in all three patients. Isochromosome 7q as the sole abnormality has been previously reported in one patient with similar clinicopathologic features. It is suggested that i(7q) is a primary, nonrandom chromosomal abnormality in hepatosplenic T γ/δ PTL.