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Acute myelomonocytic leukemia with t(10;11)(p13;q23): Heterogeneity of breakpoints at 11q23 and association with recombinase activation
Author(s) -
Height Susan E.,
Dainton Melissa G.,
Kearney Lyndal,
Swansbury G. John,
Matutes Estella,
Dyer Martin J. S.,
Treleaven Jennie G.,
Powles Ray L.,
Catovsky Daniel
Publication year - 1994
Publication title -
genes, chromosomes and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.754
H-Index - 119
eISSN - 1098-2264
pISSN - 1045-2257
DOI - 10.1002/gcc.2870110210
Subject(s) - breakpoint , biology , recombinase , leukemia , chromosomal translocation , acute myelomonocytic leukemia , gene rearrangement , acute promyelocytic leukemia , gene , recombination signal sequences , genetics , microbiology and biotechnology , cancer research , recombination activating gene , recombination , retinoic acid
The human trithorax homolog gene ( MLL ) is directly involved in over 90% of cases of acute leukemia with abnormalities of 11q23. However, involvement of other genes at 11q23 both centromeric and telomeric of MLL has been identified in different subtypes of leukemia and lymphoma. We describe a case of acute myelomonocytic leukemia (AMML; FAB type M4) with t(10;11)(p13;q23) in which the breakpoint at 11q23 was centromeric to the MLL gene and distinct from the breakpoint seen in promyelocytic leukemias with t(11;17)(q23;q22), thus providing further evidence of heterogeneity of breakpoints in 11q23 in acute leukemia. Rearrangements of immunoglobulin ( IG ) and T‐cell receptor ( TCR ) genes were also observed, with no immunophenotypic evidence for commitment to the lymphoid lineages, indicating that inappropriate activation of the recombinases may be a feature of this particular variant translocation.