The insulin‐like growth factor I receptor gene is the target for the 15q26 amplicon in breast cancer | Zendy

Almeida Anna | Zendy; Muleris Martine | Zendy; Dutrillaux Bernard | Zendy; Malfoy Bernard | Zendy

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The insulin‐like growth factor I receptor gene is the target for the 15q26 amplicon in breast cancer

Author(s) -

Almeida Anna,

Muleris Martine,

Dutrillaux Bernard,

Malfoy Bernard

Publication year - 1994

Publication title -

genes, chromosomes and cancer

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.754

H-Index - 119

eISSN - 1098-2264

pISSN - 1045-2257

DOI - 10.1002/gcc.2870110110

Subject(s) - amplicon , breast cancer , insulin like growth factor , cancer research , gene , biology , cancer , medicine , oncology , receptor , genetics , growth factor , polymerase chain reaction

We report the amplification and overexpression of the IGFIR (insulin‐like growth factor I receptor) gene in primary breast cancers with an amplification of band 15q26. The involvement of IGFIR , which may vary in frequency from 2‐3% in unselected tumor series to more than 10% in breast cancers with hsr, may represent an important event in tumor progression.

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