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The insulin‐like growth factor I receptor gene is the target for the 15q26 amplicon in breast cancer
Author(s) -
Almeida Anna,
Muleris Martine,
Dutrillaux Bernard,
Malfoy Bernard
Publication year - 1994
Publication title -
genes, chromosomes and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.754
H-Index - 119
eISSN - 1098-2264
pISSN - 1045-2257
DOI - 10.1002/gcc.2870110110
Subject(s) - amplicon , breast cancer , insulin like growth factor , cancer research , gene , biology , cancer , medicine , oncology , receptor , genetics , growth factor , polymerase chain reaction
We report the amplification and overexpression of the IGFIR (insulin‐like growth factor I receptor) gene in primary breast cancers with an amplification of band 15q26. The involvement of IGFIR , which may vary in frequency from 2‐3% in unselected tumor series to more than 10% in breast cancers with hsr, may represent an important event in tumor progression.