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Common region of deletion on the long arm of chromosome 6 in non‐Hodgkin's lymphoma and acute lymphoblastic leukaemia
Author(s) -
Menasce Lia P.,
Orphanos Vassilis,
SantibanezKoref Mauro,
Boyle John M.,
Harrison Christine J.
Publication year - 1994
Publication title -
genes, chromosomes and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.754
H-Index - 119
eISSN - 1098-2264
pISSN - 1045-2257
DOI - 10.1002/gcc.2870100411
Subject(s) - fyn , biology , locus (genetics) , lymphoma , cytogenetics , chromosome , fluorescence in situ hybridization , long arm , yeast artificial chromosome , karyotype , pathogenesis , gene mapping , gene , genetics , pathology , cancer research , immunology , medicine , kinase , proto oncogene tyrosine protein kinase src
Abstract We have used fluorescence in situ hybridisation (FISH) with a series of yeast artificial chromosome (YAC) clones that map to the long arm of chromosome 6 (6 q ) to define the region(s) of deletion in seven cases of non‐Hodgkin's lymphoma (NHL), in which a deletion of 6q had been detected by conventional cytogenetics. The FISH analysis detected two regions of deletion: (i) A proximal region flanked by M6PI (6q 14–15) and FYN (6q21), containing D6S246, which was missing in all seven cases. This locus was also found to be deleted in all six cases of acute lymphoblastic leukaemia (ALL) studied previously, (ii) A second region of 6q, which was distal to 6q23.1 (D6S238) and included ESR (6q25.l) and D6S281 (6q27), which was shown to be present in all our cases of ALL, was found to be deleted in 4 of the 7 cases of NHL. Our results support the suggestion that tumour suppressor genes, involved in the pathogenesis of lymphoid malignancies, may be present within these regions. Genes Chromosom Cancer 10:286–288 (1994). © 1994 Wiley‐Liss, Inc.