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Simple numeric abnormalities as primary karyotype changes in ovarian carcinoma
Author(s) -
Thompson Floyd H.,
Liu Yun,
Emerson Julia,
Weinstein Ronald,
Makar Rosemary,
Trent Jeffrey M.,
Taetle Raymond,
Alberts David S.
Publication year - 1994
Publication title -
genes, chromosomes and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.754
H-Index - 119
eISSN - 1098-2264
pISSN - 1045-2257
DOI - 10.1002/gcc.2870100407
Subject(s) - karyotype , chromosomal translocation , biology , chromosome , ploidy , pathology , cancer , ovarian cancer , primary tumor , ovarian carcinoma , carcinoma , cancer research , genetics , gene , medicine , metastasis
Simple near‐diploid karyotypes in ovarian cancer may indicate either primary alterations related to tumor pathogenesis or abnormalities associated with early tumor progression. We have identified a series of 13 epithelial ovarian tumors with very simple karyotypes. Specifically, these karyotypes were near‐diploid and displayed numeric abnormalities alone or combined with one or two structural alterations. The present series includes samples from 10 patients with newly diagnosed adenocarcinomas and 3 patients having borderline malignancies. Recurrent numeric abnormalities were identified and included 9/13 cases (69%) with + 12, eight cases (62%) with + 8, five cases (38%) with + 7, three cases (23%) each with + 3 or + 5, and two cases (15%) with ‐X, Five cases in this series displayed certain numeric abnormalities (+ 12, + 7, and ‐X) as the sole anomalies, thereby qualifying as primary karyotype changes. Of the 6 cases with structural abnormalities, 4 involved chromosome 19, 2 involved chromosome I, and the remaining abnormalities or translocation partners involved other chromosomes. These findings indicate that some numeric abnormalities are primary karyotype alterations in patients with malignant epithelial ovarian tumors and that chromosome 19 may be preferentially involved in structural rearrangements during early tumor progression. Genes Chromosom Cancer 10:262–266 (1994) . © 1994 Wiley‐Liss, Inc.