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Correlation of loss of heterozygosity at 11 p with tumour progression and survival in non‐small cell lung cancer
Author(s) -
Fong Kwun M.,
Zimmerman Paul V.,
Smith Peter J.
Publication year - 1994
Publication title -
genes, chromosomes and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.754
H-Index - 119
eISSN - 1098-2264
pISSN - 1045-2257
DOI - 10.1002/gcc.2870100306
Subject(s) - loss of heterozygosity , locus (genetics) , biology , cancer research , allele , genetics , medicine , oncology , gene
Loss of heterozygosity (LOH) affecting loci at 11 p 13 and 11 p 15 occurs in childhood and adult carcinomas, including non‐small cell lund cancer (NSCLC). In NSCLC, the highest reported frequency of LOH was 72% at the 11 p 13 catalase ( CAT ) locus. As this locus is centromeric to the Wilms' tumour ( WTI ) locus, possible involvement of WTI in the pathogenesis of NSCLC was considered. We thus examined 101 cases of NSCLC for LOH at the WTI and five other polymorphic loci along 11 p. At 11 p 13, the frequencies of LOH were 20% (9/46) at the FSHB locus, 9% (5/53) at the WTI locus, and 15% (6/41) at the CAT locus. The shortest region of overlap (SRO) at 11p13 was mapped centromeric to, but excluding, the WTI locus. Only adenocarcinomas showed LOH in this region. At 11 p 15, LOH affected 23% (18/77) of informative cases, with the highest frequency of 36% at the insulin ( INS ) locus. The SRO at 11 p15 was mapped telomeric to the RRMI locus. A third region, at 11 p13–15 between WTI and RRMI, was also affected by LOH. LOH at 11p correlated significantly with advanced T stage and nodal involvement in NSCLC tumours. In the squamous cell carcinoma subtype, LOH along 11p also correlated with nodal involvement. Furthermore, squamous tumours with LOH involving 11p13 loci had significantly worse survival than those without LOH. These data suggest that tumor suppressor gene(s) on 11p affect the progression of NSCLC, particularly squamous cell carcinomas. Genes Chromosom Cancer 10:183–189 (1994). © 1994 Wiley‐Liss, Inc.