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I;17 translocations and other chromosome 17 rearrangements in human primary neuroblastoma tumors and cell lines
Author(s) -
Van Roy Nadine,
Laureys Geneviève,
Cheng Ngan Ching,
Willem Pascale,
Opedenakker Ghislain,
Versteeg Rogier,
Speleman Frank
Publication year - 1994
Publication title -
genes, chromosomes and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.754
H-Index - 119
eISSN - 1098-2264
pISSN - 1045-2257
DOI - 10.1002/gcc.2870100205
Subject(s) - chromosomal translocation , fluorescence in situ hybridization , neuroblastoma , biology , chromosome , breakpoint , karyotype , genetics , chromosome 17 (human) , microbiology and biotechnology , cytogenetics , gene , fish <actinopterygii> , cell culture , cancer research , fishery
We report on the finding of a t(1;17) in two primary neuroblastomas. Subsequent fluorescence in situ hybridization (FISH) analysis revealed the presence of 1; 17 transfocations in four out of nine neuroblastoma cell lines. The chromosome 1 short arm breakpoints were determined using region‐specific probes. FISH screening also demonstrated or confirmed the presence of 11;17 translocations in three cell lines and other chromosome 17 rearrangements in those cell lines that did not carry a t(1; 17) or t(11; 17). Our data extend previous cytogenetic findings and suggest that, in addition to the known involvement of chromosome I, one or more genes on chromosome 17 also play a role in neuroblastoma development. Genes Chromosom Cancer 10:103–114 (1994). © 1994 Wiley‐Liss, Inc.
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