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Localisation of the breast‐ovarian cancer susceptibility gene (BRCAI) on 17q12–21 to an interval of ⩽IcM
Author(s) -
Smith Simon A.,
Dicioccio Richard A.,
Struewing Jeffery P.,
Easton Douglas F.,
Gallion Holly H.,
Albertsen Hans,
Mazoyer Sylvie,
Johansson Bertil,
SteichenGersdorf Elisabeth,
Stratton Mike,
Ford Debbie,
Marshall Gill,
White Raymond L.,
Piver M. Steven,
Ponder Bruce A. J.
Publication year - 1994
Publication title -
genes, chromosomes and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.754
H-Index - 119
eISSN - 1098-2264
pISSN - 1045-2257
DOI - 10.1002/gcc.2870100112
Subject(s) - ovarian cancer , breast cancer , gene , biology , microsatellite , oncology , disease , cancer , medicine , genetics , allele
Abstract A breast‐ovarian cancer susceptibility gene, BRCAI , which is responsible for disease in approximately 45% of breast cancer families and most families that contain breast and ovarian cancer, has been assigned by genetic linkage to 17q12–21. Here, we report the analysis of three marker‐disease recombinants in families that contain breast and ovarian cancer, two of which strongly suggest a location for BRCAI telomeric to D17S702, a microsatellite polymorphism, and a third which suggests a location centromeric to EDH17B , the gene encoding estradiol‐17B dehydrogenase. If the interpretation of these recombinants is correct, the results localise BRCA to an interval of ⩽cM. Genes Chrom Cancer 10:71–76 (1994). © 1994 Wiley‐Liss, Inc.