Premium
Deletion of a common region on the long arm of chromosome 6 in acute lymphoblastic leukaemia
Author(s) -
Menasce Lia P.,
Orphanos Vassilis,
SantibanezKoref Mauro,
Boyle John M.,
Harrison Christine J.
Publication year - 1994
Publication title -
genes, chromosomes and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.754
H-Index - 119
eISSN - 1098-2264
pISSN - 1045-2257
DOI - 10.1002/gcc.2870100105
Subject(s) - fyn , biology , chromosome , long arm , fluorescence in situ hybridization , genetics , gene , microbiology and biotechnology , gene deletion , mutant , kinase , proto oncogene tyrosine protein kinase src
We have characterised a region of deletion on the long arm of chromosome 6 (6q) in six cases of acute lymphoblastic leukaemia, by fluorescence in situ hybridisation, using a series of YAC clones which map to 6q. Conventional cytogenetic analysis of four of these cases had been interpreted as showing terminal deletions of 6q. We demonstrated by FISH that in all cases the deletions were interstitial. D6S246 (6q16.3) was the only marker which was missing in all six cases, indicating a common region of deletion between the markers M6PI at 6q14–15 and FYN at 6q21. Our results suggest the presence of a tumour suppressor gene within this interval. Genes Chrom Cancer 10:26–29 (1994). © 1994 Wiley‐Liss, Inc.