Premium
Allelic loss at 1 p is associated with tumor progression of meningiomas
Author(s) -
Bello M. Josefa,
Pestaña Angel,
Rey Juan A.,
De Campos Jose M.,
Kusak M. Elena,
Vaquero Jesus,
Sarasay Jose L.
Publication year - 1994
Publication title -
genes, chromosomes and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.754
H-Index - 119
eISSN - 1098-2264
pISSN - 1045-2257
DOI - 10.1002/gcc.2870090411
Subject(s) - locus (genetics) , meningioma , allele , biology , loss of heterozygosity , chromosome , tumor progression , genetics , long arm , chromosome 22 , malignant meningioma , gene , pathology , medicine
Next to chromosome 22 anomalies, deletions of the short arm of chromosome I have previously been described as the most frequent alteration detected by cytogenetic analysis of meningiomas. To determine the incidence of these deletions, we have analyzed a series of 50 meningiomas for the loss of alleles at four chromosome I loci. Thirteen samples displayed LOH for the markers studied; in one instance, the results were compatible with loss of the entire chromosome I, whereas in the other 12 samples deletions of the short arm were observed. Eleven of the meningiomas had previously been shown to have loss of alleles on chromosome 22, and 12 of them were characterized by increased tumor aggressiveness. These findings suggest that deletion of 1p (or the alteration of a locus located there) might represent a secondary, but nonrandom alteration in meningiomas, perhaps contributing to meningioma tumor progression. Genes Chrom Cancer 9:296‐298 (1994). © 1994 Wiley‐Liss. Inc.