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Germ‐line and somatic mutations of the APC gene in patients with turcot syndrome and analysis of APC mutations in brain tumors
Author(s) -
Mori Takahiro,
Nagase Hiroki,
Horii Akira,
Miyoshi Yasuo,
Nakatsuru Shuichi,
Aoki Takahisa,
Arakawa Hirofumi,
Nakamura Yusuke,
Shimano Takashi,
Yanagisawa Akio,
Ushio Yukitaka,
Takano Sadamu,
Ogawa Michio,
Nakamura Masato,
Shibuya Masabumi,
Nishikawa Ryo,
Matsutani Masao,
Hayashi Yasuhide,
Takahashi Hitoshi,
Ikuta Fusahiro,
Nishihira Tetsuro,
Mori Shozo
Publication year - 1994
Publication title -
genes, chromosomes and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.754
H-Index - 119
eISSN - 1098-2264
pISSN - 1045-2257
DOI - 10.1002/gcc.2870090304
Subject(s) - oligodendroglioma , adenomatous polyposis coli , somatic cell , biology , glioma , cancer research , familial adenomatous polyposis , germline mutation , neuroepithelial cell , medulloblastoma , astrocytoma , brain tumor , mutation , pathology , tumor suppressor gene , gene , colorectal cancer , cancer , medicine , genetics , carcinogenesis , embryonic stem cell
The Turcot syndrome (TS) is a rare, probably autosomal recessive, disorder characterized by development of primary neuroepithelial tumors of the central nervous system (CNS) and numerous adenomatous colorectal polyps. To examine the possible involvement of mutations of the APC gene, which is responsible for familial adenomatous polyposis (FAP), in Turcot syndrome, we examined DNAs from TS patients for alterations in this gene by means of ribonuclease protection analysis. Germ‐line APC mutations were detected in each of three unrelated cases of TS, and additional (somatic) mutations were observed in colonic adenomas that had developed in one of these patients. However, no somatic mutations in APC were found among 91 neuroepithelial tumors (medulloblastoma, glioblastoma, astrocytoma, and oligodendroglioma). whether sporadic or associated with TS. These results suggest that the APC gene is associated with pathogenesis of one feature of TS, but that at least one other gene is responsible for the genesis of neuroepithelial tumors in the CNS. Genes Chrom Cancer 9:168‐172 (1994). © 1994 Wiley‐Liss, Inc.