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Amplification of the anonymous marker D17S67 in malignant astrocytomas
Author(s) -
Bijlsma Emilia K.,
Westerveld Andries,
Hulsebos Theo J. M.,
Leenstra Sieger,
Bosch D. Andries
Publication year - 1994
Publication title -
genes, chromosomes and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.754
H-Index - 119
eISSN - 1098-2264
pISSN - 1045-2257
DOI - 10.1002/gcc.2870090213
Subject(s) - loss of heterozygosity , gene duplication , chromosome , malignancy , biology , astrocytoma , cancer research , gene , epidermal growth factor receptor , cancer , pathology , genetics , glioma , medicine , allele
Abstract Loss of heterozygosity (LOH) for chromosome arms 9p, 10p, 10q, and 17p and amplification of the epidermal growth factor receptor ( EGFR ) gene have been identified as frequent genetic changes in malignant astrocytomas. We have found amplification of the anonymous marker D17S67 on chromosome arm 17p in 10% (3 of 30 cases) of astrocytomas of the highest malignancy grade. The tumors with D17S67 amplification displayed other genetic changes on chromosome 17, including additional amplifications and deletions. All three patients with D17S67 amplification developed severe brain edema and died within I month after operation. Genes Chrom Cancer 9:148‐152 (1994). © 1994 Wiley‐Liss, Inc.