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Band 11 q 13 is nonrandomly rearranged in hibernomas
Author(s) -
Mrœzek Krzysztof,
Karakousis Constantine P.,
Bloomfield Clara D.
Publication year - 1994
Publication title -
genes, chromosomes and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.754
H-Index - 119
eISSN - 1098-2264
pISSN - 1045-2257
DOI - 10.1002/gcc.2870090212
Subject(s) - chromosomal translocation , abnormality , pathogenesis , adipose tissue , biology , karyotype , gene , genetics , chromosome , medicine , endocrinology , immunology , psychiatry
Cytogenetic study of a short‐term culture from a hibernoma, a very rare benign proliferation of the brown fat, demonstrated a four‐break translocation t(5;7;11;17)(p14;q11.23;q13.1‐13.3;p11.2) as the sole abnormality in all analyzed cells. Complex translocations involving band 11 q 13 have also been detected in the two other published cases of hibernoma. The consistent finding of 11 q 13 rearrangements appears to distinguish hibernoma from other benign adipose tissue tumors cytogenetically and suggests that 11 q 13 changes may play an important role in hibernoma pathogenesis. Genes Chrom Cancer 9:145‐147 (1994) . Inc.© 1994 Wiley‐Liss, Inc.