Band 11 q 13 is nonrandomly rearranged in hibernomas

Cytogenetic study of a short‐term culture from a hibernoma, a very rare benign proliferation of the brown fat, demonstrated a four‐break translocation t(5;7;11;17)(p14;q11.23;q13.1‐13.3;p11.2) as the sole abnormality in all analyzed cells. Complex translocations involving band 11 q 13 have also been detected in the two other published cases of hibernoma. The consistent finding of 11 q 13 rearrangements appears to distinguish hibernoma from other benign adipose tissue tumors cytogenetically and suggests that 11 q 13 changes may play an important role in hibernoma pathogenesis. Genes Chrom Cancer 9:145‐147 (1994) . Inc.© 1994 Wiley‐Liss, Inc.