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Loss of chromosome band 8q24 in sporadic osteocartilaginous exostoses
Author(s) -
Mertens Fredrik,
Helm Sverre,
Mitelman Felix,
Mandahl Nils,
Rydholm Anders,
Kreicbergs Andris,
Willén Helena,
Jonsson Kjell
Publication year - 1994
Publication title -
genes, chromosomes and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.754
H-Index - 119
eISSN - 1098-2264
pISSN - 1045-2257
DOI - 10.1002/gcc.2870090103
Subject(s) - biology , karyotype , somatic cell , genetics , loss of heterozygosity , allele , phenotype , tumor suppressor gene , mutation , chromosome band , chromosome , gene , cancer research , carcinogenesis , gene mapping
We have karyotyped eight sporadic osteocartilaginous exostoses (OCE), a tumor type not characterized cytogenetically before. Five tumors had only normal karyotypes, whereas three displayed the following abnormal karyotypes: 46,XY,del(8)(q24.1); 46,XX,del(8)(q22), t(8;14)(q24. 1;q32); and 46,XY,der(8)t(1;8)(q21;q24), inv(12)(p1 1q13). All three aberrant cases thus had structural rearrangements leading to loss of the distal part of 8q. This is of particular interest because multiple OCE are part of the disease phenotype in patients with the autosomal dominant tricho‐rhino‐phalangeal syndrome type II (TRP II), many of whom have constitutional loss of genetic material from 8q24.1. We hypothesize that band 8q24.1 harbors a tumor suppressor gene, the homozygous inactivation of which is important in the genesis of both inherited and sporadic OCE. In the familial form, i.e., in TRP II, loss or functional inactivation of one allele is inherited and only the second mutation is due to a somatic event, whereas both mutations are somatic in the sporadic forms. This hypothesis can be tested by analysis of sporadic and inherited OCE for homozygous loss of 8q24 material with molecular genetic techniques. Genes Chrom Cancer 9:8‐12 (1994). ©1994 Wiley‐Liss, Inc.