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Deletion of 3p25→pter in a primary follicular thyroid carcinoma and its metastasis
Author(s) -
Roque Lúcia,
Castedo Sérgio,
Clode Ana,
Soares Jorge
Publication year - 1993
Publication title -
genes, chromosomes and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.754
H-Index - 119
eISSN - 1098-2264
pISSN - 1045-2257
DOI - 10.1002/gcc.2870080311
Subject(s) - thyroid carcinoma , follicular carcinoma , follicular phase , thyroid , pathology , metastasis , carcinoma , medicine , biology , cancer research , cancer , papillary carcinoma
We report the cytogenetic analysis of a follicular thyroid carcinoma and its bone metastasis. Both lesions had identical chromosomal abnormalities, with a der(3)t(2;3)(q13;p25) as the most likely primary clonal alteration. Our findings corroborate previous observations of frequent 3p deletions in thyroid follicular carcinomas and suggest that the minimal chromosomal region of loss in these tumors is 3p25→pter. © 1993 Wiley‐Liss, Inc.