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Mapping of the 19p13 breakpoint in an ovarian carcinoma between the INSR and TCF3 Loci
Author(s) -
Åman Pierre,
Pejovic Tanja,
Wennborg Anders,
Heim Sverre,
Mitelman Felix
Publication year - 1993
Publication title -
genes, chromosomes and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.754
H-Index - 119
eISSN - 1098-2264
pISSN - 1045-2257
DOI - 10.1002/gcc.2870080212
Subject(s) - breakpoint , biology , cancer research , genetics , medicine , oncology , bioinformatics , computational biology , gene , chromosomal translocation
Chromosome rearrangements involving band 19p13 have been described in about half of all ovarian carcinomas. Four ovarian carcinomas with translocations of 19p13 were investigated with 11 DNA probes for markers localized to this band. All markers exhibited normal restriction patterns, suggesting that they were not rearranged. The 19p13 breakpoint of one tumor was mapped to a location between the INSR and the TCF3 loci. © 1993 Wiley‐Liss, Inc.