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Ring chromosome 12 resulting from nonrandom telomeric associations with the short arm of chromosome 15 in a cerebellar astrocytoma
Author(s) -
Sawyer Jeffrey R.,
Sammartino Gael,
Husain M.,
Lewis Jane M.,
Anderson Bruce,
Boop Frederick A.
Publication year - 1993
Publication title -
genes, chromosomes and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.754
H-Index - 119
eISSN - 1098-2264
pISSN - 1045-2257
DOI - 10.1002/gcc.2870080202
Subject(s) - telomere , chromosome , ring chromosome , biology , chromosome 21 , astrocytoma , genetics , ring (chemistry) , dna , karyotype , gene , glioma , chemistry , organic chemistry
Ring chromosome 12 was found in an untreated cerebellar astrocytoma apparently resulting from nonrandom telomeric associations involving the short arm of chromosome 15, and both the long and short arms of chromosome 12. The clonal nonrandom telomeric associations of 15p to both ends of the chromosome 12 were transitory, but appear to be the precursor lesion in the evolution to ring chromosome 12 in this tumor. A multistep process in the formation of a ring chromosome resulting from nonrandom telomeric associations to both telomeres is illustrated. © 1993 Wiley‐Liss, Inc.