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Oligoclonal B‐cell leukemia characterized by spontaneous cell division and telomere association
Author(s) -
Crossen Peter E.,
Tully Sandra M.,
Benjes Suzanne M.,
Hollings Peter E.,
Beard Michael E. J.,
Nimmo Joy C.,
Morrison Mary J.
Publication year - 1993
Publication title -
genes, chromosomes and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.754
H-Index - 119
eISSN - 1098-2264
pISSN - 1045-2257
DOI - 10.1002/gcc.2870080109
Subject(s) - telomere , biology , chromosomal translocation , immunoglobulin gene , gene , antibody , germline , leukemia , chronic lymphocytic leukemia , chromosome instability , genetics , population , microbiology and biotechnology , chromosome , immunology , medicine , environmental health
Cytogenetic analysis of unstimulated cultures from a female patient with chronic B‐cell leukemia (CLL) revealed three cytogenetically distinct clones, suggesting that the patient's leukemia was oligoclonal. Immunoglobulin heavy chain gene rearrangement studies revealed 1 germline and 4 rearranged bands, indicative of an oligoclonal leukemc population. Further evidence of oligoclonality was provided by X‐linked RFLP studies. This is the first report of oligoclonality in CLL demonstrated by cytogenetic, immunoglobulin gene rearrangement, and X‐chromosome inactivation studies. In addition to oligoclonality, the patient's leukemk cells exhibited telomere association, a Robertsonian translocation, and clonal evolution, suggesting an underlying genomic instability. © 1993 Wiley‐Liss, Inc.