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Ovarian germ cell tumor evolving to myelodysplasia
Author(s) -
Mascarello James T.,
Cajulis Trilla R.,
Billman Glenn F.,
Spruce Wayne E.
Publication year - 1993
Publication title -
genes, chromosomes and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.754
H-Index - 119
eISSN - 1098-2264
pISSN - 1045-2257
DOI - 10.1002/gcc.2870070408
Subject(s) - germ cell , biology , cancer research , microbiology and biotechnology , medicine , genetics , gene
We present the case of a 14‐year‐old girl in whom a myelodysplastic syndrome was diagnosed 9 months after surgical resection and chemotherapy for an ovarian germ cell tumor. Cells from her marrow were characterized by trisomy 8 and an isochromosome 12p, a marker that appears to be unique to germ cell tumors. The presence of the same two anomalies in her original tumor was demonstrated by fluorescence in situ hybridization study of interphase cells in paraffin‐embedded tissues and thus provided strong evidence that the two neoplasms had a common clonal origin. © 1993 Wiley‐Liss, Inc.