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Near‐haploid karyotype in a squamous cell lung carcinoma
Author(s) -
Drouin Valérie,
Viguié Franck,
Debesse Bernard
Publication year - 1993
Publication title -
genes, chromosomes and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.754
H-Index - 119
eISSN - 1098-2264
pISSN - 1045-2257
DOI - 10.1002/gcc.2870070405
Subject(s) - karyotype , ploidy , biology , clone (java method) , chromosome , genetics , gene duplication , cytogenetics , microbiology and biotechnology , dna , gene
Cytogenetic analysis of a squamous cell lung carcinoma revealed a near‐haploid karyotype with 27 chromosomes, in both primary cultures and an established cell line. The only chromosomes with two homologs present were chromosomes X, 5, 7, and 22. The two X chromosomes were early and late replicating, respectively. No structural rearrangements could be detected. In vitro, the clone evolved by duplication towards hyperdiploidy with 54 chromosomes. © 1993 Wiley‐Liss, Inc.