Clonal t(8;14)(p11;q31) in a case of reactive lymphoproliferation | Zendy

Zhang Yanming | Zendy; Schlegelberger Brigitte | Zendy; Plendl Hansjörg | Zendy; Sonnen Ruth | Zendy; Kuse Rolf | Zendy; Feller Alfred C. | Zendy; Grote Werner | Zendy

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Clonal t(8;14)(p11;q31) in a case of reactive lymphoproliferation

Author(s) -

Zhang Yanming,

Schlegelberger Brigitte,

Plendl Hansjörg,

Sonnen Ruth,

Kuse Rolf,

Feller Alfred C.,

Grote Werner

Publication year - 1993

Publication title -

genes, chromosomes and cancer

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.754

H-Index - 119

eISSN - 1098-2264

pISSN - 1045-2257

DOI - 10.1002/gcc.2870070309

Subject(s) - chromosomal translocation , clone (java method) , biology , southern blot , gene rearrangement , immunoglobulin heavy chain , gene , lymphoma , antibody , microbiology and biotechnology , chromosome , cancer research , genetics , immunology

A clone with an unbalanced translocation t(8;14)(p11;q31), resulting in deletion of the distal part of the long arm of chromosome 14, 14q31 → 14qter, was detected in a case of Piringer's lymphadenitis. Histopathologically no atypical cells or other signs of malignant lymphoma were found. Southern blot analyses showed no rearrangement of the immunoglobulin heavy chain gene ( IGH ) or the T‐cell receptor γ chain ( TCRG ) gene. The case exemplifies that the detection of a chromosomally aberrant clone does not necessarily prove that a lymphoproliferative process is malignant. © 1993 Wiley‐Liss, Inc.

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