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Clonal t(8;14)(p11;q31) in a case of reactive lymphoproliferation
Author(s) -
Zhang Yanming,
Schlegelberger Brigitte,
Plendl Hansjörg,
Sonnen Ruth,
Kuse Rolf,
Feller Alfred C.,
Grote Werner
Publication year - 1993
Publication title -
genes, chromosomes and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.754
H-Index - 119
eISSN - 1098-2264
pISSN - 1045-2257
DOI - 10.1002/gcc.2870070309
Subject(s) - chromosomal translocation , clone (java method) , biology , southern blot , gene rearrangement , immunoglobulin heavy chain , gene , lymphoma , antibody , microbiology and biotechnology , chromosome , cancer research , genetics , immunology
Abstract A clone with an unbalanced translocation t(8;14)(p11;q31), resulting in deletion of the distal part of the long arm of chromosome 14, 14q31 → 14qter, was detected in a case of Piringer's lymphadenitis. Histopathologically no atypical cells or other signs of malignant lymphoma were found. Southern blot analyses showed no rearrangement of the immunoglobulin heavy chain gene ( IGH ) or the T‐cell receptor γ chain ( TCRG ) gene. The case exemplifies that the detection of a chromosomally aberrant clone does not necessarily prove that a lymphoproliferative process is malignant. © 1993 Wiley‐Liss, Inc.