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Deletion of chromosome 11 and of 14q sequences in neuroblastoma
Author(s) -
Srivatsan Eri S.,
Ying Kuang Lin,
Seeger Robert C.
Publication year - 1993
Publication title -
genes, chromosomes and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.754
H-Index - 119
eISSN - 1098-2264
pISSN - 1045-2257
DOI - 10.1002/gcc.2870070106
Subject(s) - chromosomal translocation , biology , chromosome , genetics , neuroblastoma , restriction fragment length polymorphism , chromosome 22 , chromosomal abnormality , marker chromosome , microbiology and biotechnology , karyotype , gene , cell culture , polymerase chain reaction
Restriction fragment length polymorphism (RFLP) analysis carried out on 45 primary neuroblastomas showed deletion of chromosome 11 sequences in 12 of 37 (32%) informative cases. Both 11p and 11q probes were informative in seven tumors; loss of all of chromosome 11, of only 11p sequences, and of only 11q sequences was observed in 4, 1, and 2 tumors, respectively. A cytogenetic abnormality involving translocation of chromosome arm 11q to chromosome arm 1p was observed in a primary tumor. Deletion of 14q was observed in 6 of 27 (22%) informative cases. Deletion of chromosome 11 but not 14q may correlate with regional and metastatic disease. These results suggest a possible role for sequences localized to chromosome 11 and to 14q in the development and/or progression of neuroblastoma. © 1993 Wiley‐Liss, Inc.