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A second case of trisomy 8 in philadelphia chromosome (Ph)‐negative cells during the course of Ph‐positive chronic myelocytic leukemia
Author(s) -
BilhouNabera C.,
Marit G.,
Devianne I.,
Viard F.,
Salzes S.,
Montastruc M.,
Renoux M.,
Broustet A.,
Reiffers J.,
Bernard Ph.
Publication year - 1993
Publication title -
genes, chromosomes and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.754
H-Index - 119
eISSN - 1098-2264
pISSN - 1045-2257
DOI - 10.1002/gcc.2870060414
Subject(s) - clone (java method) , trisomy , myelocytic leukemia , philadelphia chromosome , trisomy 8 , peripheral blood , medicine , leukemia , chromosome , microbiology and biotechnology , immunology , chemistry , biology , karyotype , genetics , chromosomal translocation , dna , gene
A Ph‐positive CML patient who had received a peripheral blood stem cell autograft in chronic phase demonstrated a transient regression of the Ph‐positive clone with the concurrent appearance of another clone with trisomy 8. This latter clone disappeared when the patient received α‐interferon. © 1993 Wiley‐Liss, Inc.