Premium
Clonal chromosome aberrations in cell cultures of synovial tissue from patients with rheumatoid arthritis
Author(s) -
Ermis Ayhan,
Hopf Thomas,
Hanselmann Rainer,
Remberger Klaus,
Welter Cornelius,
Dooley Steven,
Zang Klaus D.,
Henn Wolfram
Publication year - 1993
Publication title -
genes, chromosomes and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.754
H-Index - 119
eISSN - 1098-2264
pISSN - 1045-2257
DOI - 10.1002/gcc.2870060407
Subject(s) - rheumatoid arthritis , chromosome , cell , pathology , biology , medicine , immunology , genetics , gene
Abstract Cytogenetic analysis of primary cell cultures and/or passages 1–3 of synovial tissue from seven patients with rheumatoid arthritis was performed. As the only recurrent chromosome aberration, trisomy 7 was found in six of seven cultures. In four cultures, trisomy 7 occurred as a clonal change in up to 20% of the analyzed cells, with an increase of the proportion of cells with +7 with the duration of the in vitro culture. Apart from this recurrent change, a variety of partly clonal, partly nonclonal numerical and structural chromosome aberrations were observed in all cases. These findings support the view that clonal chromosome aberrations may play a role in the pathogenesis of invasive growth of the synovial tissue in rheumatoid arthritis although the localized synovial hyperproliferation is not a true neoplastic process. © 1993 Wiley‐Liss, Inc.