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Clonal chromosome aberrations in neurinomas
Author(s) -
Bello M. Josefa,
De Campos José M.,
Kusak M. Elena,
Vaquero Jesús,
Sarasa José L.,
Pestaña Angel,
Rey Juan A.
Publication year - 1993
Publication title -
genes, chromosomes and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.754
H-Index - 119
eISSN - 1098-2264
pISSN - 1045-2257
DOI - 10.1002/gcc.2870060403
Subject(s) - monosomy , biology , chromosome , karyotype , genetics , microbiology and biotechnology , gene
Chromosome studies were performed after short‐term in vitro culture of 39 samples from neurinomas and two samples from malignant schwannomas. Clonal abnormalities involving chromosome 22 were observed in 23 cases, as the sole chromosomal deviation in 12 of them. In 11 samples, other clonal numerical and/or structural aberrations were detected in addition to loss of chromosome 22, either in the same cells or in cells other than those having monosomy 22. Within the group of neurinomas with no involvement of chromosome 22, there were again two cytogenetically distinctive subgroups: one with an abnormal karyotype, and the second with a normal chromosome complement. Our findings confirm that monosomy 22 is a characteristic feature of this type of neoplasm, but also suggest the existence of different cytogenetic subgroups of neurinomas. © 1993 Wiley‐Liss, Inc.