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Telomeric associations and loss of telomeric DNA repeats in renal tumors
Author(s) -
Holzmann Karlheinz,
Blin Nikolaus,
Welter Cornelius,
Zang Klaus D.,
Seitz Gerhard,
Henn Wolfram
Publication year - 1993
Publication title -
genes, chromosomes and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.754
H-Index - 119
eISSN - 1098-2264
pISSN - 1045-2257
DOI - 10.1002/gcc.2870060308
Subject(s) - telomere , biology , renal cell carcinoma , oncocytoma , pathogenesis , dna , chromosome , renal oncocytoma , chromophobe cell , pathology , carcinoma , microbiology and biotechnology , cancer research , genetics , kidney , gene , clear cell , medicine , immunology
Abstract In a series of cytogenetically analyzed renal tumors of different histological types (chromophobe carcinoma, clear‐cell carcinoma, chromophilic carcinoma, and oncocytoma) and normal renal tissue, the length of the telomeric DNA repeats was assessed using a (TTAGGG) 3 oligonucleotide probe. A strong correlation was noted between pronounced telomere shortening and the appearance of telomeric associations of chromosomes. These data suggest an etiologic role of the loss of telomeric DNA repeats in the formation of telomeric associations and a possible involvement of this mechanism in the pathogenesis of chromosome aberrations in human tumors. © 1993 Wiley‐Liss, Inc.