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Rearrangements of the RARA and PML genes in a cytogenetic variant of acute promyelocytic leukemia
Author(s) -
Baranger L.,
Gardembas M.,
Hillion J.,
Foussard C.,
Ifrah N.,
Boasson M.,
Berger R.
Publication year - 1993
Publication title -
genes, chromosomes and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.754
H-Index - 119
eISSN - 1098-2264
pISSN - 1045-2257
DOI - 10.1002/gcc.2870060209
Subject(s) - chromosomal translocation , acute promyelocytic leukemia , promyelocytic leukemia protein , biology , chromosome 15 , gene , chromosome 17 (human) , chromosome , retinoic acid , genetics , microbiology and biotechnology , leukemia , cancer research , chromosome 19
Acute promyelocytic leukemia (APL) is usually associated with the translocation t(15;17)(q22;q12‐21), which disrupts the retinoic acid receptor alpha ( RARA ) gene on chromosome 17 and the PML gene on chromosome 15. We report a patient with typical APL without the common t(15;17). Cytogenetic studies demonstrated a normal appearance of chromosomes 15, while a small marker seemed to be an i(17q—). Molecular analysis showed RARA and PML rearrangements, suggesting that the chromosome abnormality corresponded to a variant translocation. © 1993 Wiley‐Liss, Inc.