Rearrangements of the  RARA  and  PML  genes in a cytogenetic variant of acute promyelocytic leukemia | Zendy

Baranger L. | Zendy; Gardembas M. | Zendy; Hillion J. | Zendy; Foussard C. | Zendy; Ifrah N. | Zendy; Boasson M. | Zendy; Berger R. | Zendy

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Rearrangements of the RARA and PML genes in a cytogenetic variant of acute promyelocytic leukemia

Author(s) -

Baranger L.,

Gardembas M.,

Hillion J.,

Foussard C.,

Ifrah N.,

Boasson M.,

Berger R.

Publication year - 1993

Publication title -

genes, chromosomes and cancer

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.754

H-Index - 119

eISSN - 1098-2264

pISSN - 1045-2257

DOI - 10.1002/gcc.2870060209

Subject(s) - chromosomal translocation , acute promyelocytic leukemia , promyelocytic leukemia protein , biology , chromosome 15 , gene , chromosome 17 (human) , chromosome , retinoic acid , genetics , microbiology and biotechnology , leukemia , cancer research , chromosome 19

Acute promyelocytic leukemia (APL) is usually associated with the translocation t(15;17)(q22;q12‐21), which disrupts the retinoic acid receptor alpha ( RARA ) gene on chromosome 17 and the PML gene on chromosome 15. We report a patient with typical APL without the common t(15;17). Cytogenetic studies demonstrated a normal appearance of chromosomes 15, while a small marker seemed to be an i(17q—). Molecular analysis showed RARA and PML rearrangements, suggesting that the chromosome abnormality corresponded to a variant translocation. © 1993 Wiley‐Liss, Inc.

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