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Chromosome analysis of 20 breast carcinomas: Cytogenetic multiclonality and karyotypic‐pathologic correlations
Author(s) -
Pandis Nikos,
Heim Sverre,
Bardi Georgia,
Idvall Ingrid,
Mandahl Nils,
Mitelman Felix
Publication year - 1993
Publication title -
genes, chromosomes and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.754
H-Index - 119
eISSN - 1098-2264
pISSN - 1045-2257
DOI - 10.1002/gcc.2870060110
Subject(s) - biology , karyotype , pathology , malignancy , chromosome , cytogenetics , breast carcinoma , carcinoma , chromosome abnormality , breast cancer , genetics , cancer , medicine , gene
Abstract Short‐term cultures from 20 breast carcinomas were analyzed cytogenetically. A normal female chromosome complement was found in 4 cases. Clonal chromosome aberrations were detected in 16 tumors. In 10 tumors, multiple cytogenetic clones were found; in 2 cancers the clones were related, reflecting clonal evolution, but in the remaining 8 tumors the clones were cytogenetically unrelated, indicating clonal heterogeneity in the origin of the tumor parenchyma. Correlation analysis between karyotypic and pathologic parameters indicated that cases with complex karyotypes and/or cytogenetically unrelated clones, when compared with cases with a single simple karyotypic abnormality, were generally of higher histologic malignancy grade, had more mitoses in the histologic sections, and also more often had carcinoma in situ lesions in the same breast. © 1993 Wiley‐Liss, Inc.