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11q deletions in human colorectal carcinomas: Cytogenetics and restriction fragment length polymorphism analysis
Author(s) -
Keldysh Peter L.,
Dragani Tommaso A.,
Fleischman Elena W.,
Konstantinova Liliya N.,
Perevoschikov Alexander G.,
Pierotti Marco A.,
Porta Giuseppe Della,
Kopnin Boris P.
Publication year - 1993
Publication title -
genes, chromosomes and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.754
H-Index - 119
eISSN - 1098-2264
pISSN - 1045-2257
DOI - 10.1002/gcc.2870060109
Subject(s) - loss of heterozygosity , biology , cytogenetics , restriction fragment length polymorphism , chromosome , genetics , rectum , allele , microbiology and biotechnology , gene , polymerase chain reaction , medicine
Deletions and/or allelic losses of a portion of the long arm of chromosome 11 were discovered by cytogenetic and restriction fragment length polymorphism analyses in 23 of 39 (59%) informative cases of colorectal carcinoma. By comparing the patterns of loss of heterozygosity and chromosome rearrangements in different patients, we could map a common target region to 11q22‐23. This region may contain a tumor suppressor gene, the inactivation of which may be involved in the development of tumors of the large intestine. The subgroup of malignancies with 11q alterations seemed to be enriched by tumors that were located in the rectum, that were Dukes' stage A, and that were well differentiated and mucin producing.© 1993 Wiley‐Liss,