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Isochromosome 1q in acute monocytic leukemia: A new nonrandom association
Author(s) -
Hawkins Jacqueline M.,
Wood Marion,
Wright Faith,
SeekerWalker Lorna M.
Publication year - 1992
Publication title -
genes, chromosomes and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.754
H-Index - 119
eISSN - 1098-2264
pISSN - 1045-2257
DOI - 10.1002/gcc.2870050213
Subject(s) - isochromosome , monocytic leukemia , acute monocytic leukemia , thp1 cell line , leukemia , acute leukemia , abnormality , biology , cancer research , chromosome , genetics , karyotype , medicine , cell culture , gene , psychiatry
We report a case of de novo acute monocytic leukemia in a 25‐year‐old man in whom the sole clonal cytogenetic abnormality was an additional isochromosome Iq. Cytogenetic polymorphisms indicate that, in addition to the formation of the isochromosome, a duplication of the remaining normal chromosome I had taken place. Other reported cases suggest an association between acute monocytic leukemia and i(lq).