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Translocation t(11; 14)(q 13;q32) in chronic lymphoid disorders
Author(s) -
BritoBabapulie V.,
Ellis J.,
Matutes E.,
Oscier D.,
Khokhar T.,
MacLennan K.,
Catovsky D.
Publication year - 1992
Publication title -
genes, chromosomes and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.754
H-Index - 119
eISSN - 1098-2264
pISSN - 1045-2257
DOI - 10.1002/gcc.2870050210
Subject(s) - immunophenotyping , chromosomal translocation , chronic lymphocytic leukemia , lymphoproliferative disorders , pathology , hairy cell leukemia , lymphoma , lymphoplasmacytic lymphoma , prolymphocytic leukemia , biology , leukemia , follicular lymphoma , immunology , medicine , flow cytometry , waldenstrom macroglobulinemia , genetics , gene
The translocation t( 11; I4)(q 13;q32) has been described in a spectrum of B‐lymphoproliferative diseases and involves a putative oncogene, BCLI , which maps to chromosome band 11q13. Recent evidence indicates that this abnormality may delineate particular subtypes of lymphoma, such as intermediate lymphocytic and centrocytic lymphomas. Thus the possible significance of the t(111;14) within B‐cell disorders should be reexamined in the light of a more objective approach to classifying these diseases by morphology, histology, and immunophenotype. We describe 16 patients with t(11;14)(q13;q32) from a series of 90 patients with chronic lymphoid disorders in whom clonal chromosome abnormalities were detected. All the cases were leukemic: prolymphocytic (B‐PLL; 4 / 15 cases), chronic lymphocytic leukemia (CLL) with increase in prolymphocytes ( 2 / 9 cases), or non‐Hodgkin lymphoma in leukemic phase, intermediate ( 3 / 4 cases), lymphoplasmacytic ( 2 / 2 cases), splenic lymphoma with villous lymphocytes ( 4 / 18 cases), and follicular (I case). None of the CLL (25) or hairy cell leukemia cases (15) had t(11;14). Our findings showed that t(11;14) occurred in leukemias of mature B cells with lymphoplasmacytic features as judged by morphology and immunophenotype.