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Detection of loss of heterozygosity at the human TP53 locus using a dinucleotide repeat polymorphism
Author(s) -
Jones Michael H.,
Nakamura Yusuke
Publication year - 1992
Publication title -
genes, chromosomes and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.754
H-Index - 119
eISSN - 1098-2264
pISSN - 1045-2257
DOI - 10.1002/gcc.2870050113
Subject(s) - loss of heterozygosity , locus (genetics) , dinucleotide repeat , genetics , biology , microsatellite , allele , gene
Loss of heterozygosity at the TP53 locus occurs frequently in many types of cancer and requires polymorphic markers for detection. Several polymorphisms at the TP53 locus have been described previously, and polymerase chain reaction (PCR)‐based assays have been developed to detect these polymorphisms. However, these polymorphisms have relatively low levels of heterozygosity and are often uninformative. We report here the detection of loss of heterozygosity at the TP53 locus in various human cancers by using a highly informative dinucleotide repeat polymorphism.