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Malignant fibrous histiocytoma of the brain in a six‐year‐old girl
Author(s) -
Biegel Jaclyn A.,
Perilongo Giorgio,
Rorke Lucy B.,
Parmiter Annette H.,
Emanuel Beverly S.
Publication year - 1992
Publication title -
genes, chromosomes and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.754
H-Index - 119
eISSN - 1098-2264
pISSN - 1045-2257
DOI - 10.1002/gcc.2870040406
Subject(s) - karyotype , girl , abnormality , pathology , central nervous system , soft tissue , cytogenetics , medicine , chromosome , biology , anatomy , genetics , psychiatry , gene
We have prepared karyotypes from a malignant fibrous histiocytoma (MFH) of the brain of a 6‐year‐old girl. Sporadic cases of MFH in the central nervous system have been reported. However, to our knowledge, this is the first central nervous system tumor to be subjected to cytogenetic analysis. The tumor demonstrated a complex karyotype, with a variety of numerical and structural abnormalities. Although no specific cytogenetic abnormality was observed, the karyotype of this case was similar to those reported for adult MFH of soft tissues.