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dup(12)(q13→qter) in two t(14;18)‐negative follicular b‐non‐hodgkin's lymphomas
Author(s) -
Wlodarska Iwona,
Mecucci Cristina,
Vandenberghe Elisabeth,
Hilliker Carl,
Schoenmakers Eric,
Stul Michel,
Marynen Peter,
Cassiman JeanJacques,
Berghe Herman Van Den,
De WolfPeeters Chris,
Thomas José
Publication year - 1992
Publication title -
genes, chromosomes and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.754
H-Index - 119
eISSN - 1098-2264
pISSN - 1045-2257
DOI - 10.1002/gcc.2870040405
Subject(s) - dup , trisomy , lymphoma , fluorescence in situ hybridization , pathology , gene duplication , biology , chronic lymphocytic leukemia , follicular lymphoma , non hodgkin's lymphoma , karyotype , leukemia , chromosome , cancer research , medicine , gene , immunology , genetics
Two t(14;18)‐negative follicular B‐non‐Hodgkin's lymphomas with the same chromosomal abnormality, dup(12)(q13→qter), are presented. The absence of a BCL2 gene rearrangement was confirmed by molecular studies in both cases. Instead, duplication of a 12q segment was found. Further evidence for the presence of the dup(12)(q13→qter) was found using fluorescence in situ hybridization. dup(12q) may be equivalent to the trisomy 12 originally described in B‐chronic lymphocytic leukemia. This chromosome anomaly has also been reported in B‐non‐Hodgkin's lymphomas, usually in association with other chromosome anomalies and a more aggressive tumor phenotype. Occurrence of dup(12q) in two histologically similar cases of follicular small cleaved‐cell lymphoma without a typical t(14;18), suggests that this karyotypic change may play a critical role in some cases of follicle center‐cell lymphomas.