Trisomy 8 in philadelphia chromosome (ph 1 )‐negative cells in the course of ph 1 ‐positive chronic myelocytic leukemia | Zendy

Casali Monica | Zendy; Truglio Fabrizio | Zendy; Maserati Emanuela | Zendy; Pasquali Francesco | Zendy; Milone Giuseppe | Zendy; Raimondo Francesco Di | Zendy; Parrinello Gisella | Zendy

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Trisomy 8 in philadelphia chromosome (ph 1 )‐negative cells in the course of ph 1 ‐positive chronic myelocytic leukemia

Author(s) -

Casali Monica,

Truglio Fabrizio,

Maserati Emanuela,

Pasquali Francesco,

Milone Giuseppe,

Raimondo Francesco Di,

Parrinello Gisella

Publication year - 1992

Publication title -

genes, chromosomes and cancer

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.754

H-Index - 119

eISSN - 1098-2264

pISSN - 1045-2257

DOI - 10.1002/gcc.2870040314

Subject(s) - myelocytic leukemia , busulfan , trisomy , philadelphia chromosome , karyotype , bone marrow , chromosome , trisomy 8 , chemistry , microbiology and biotechnology , leukemia , chromosomal translocation , medicine , biology , genetics , biochemistry , chemotherapy , cyclophosphamide , gene

A female patient with chronic myelocytic leukemia (CML) in chronic phase after busulfan and interferon treatment had four different cell lines in her bone marrow. In addition to cells with a normal karyotype there were cells with the Philadelphia chromosome (Ph 1 ), cells with trisomy 8 and a Ph 1 , and cells with trisomy 8 as the sole anomaly.

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