Trisomy 5 and trisomy 7 are nonrandom aberrations in pigmented villonodular synovitis: Confirmation of trisomy 7 in uncultured cells | Zendy

Fletcher Jonathan A. | Zendy; Henkle Carol | Zendy; Atkins Leonard | Zendy; Rosenberg Andrew E. | Zendy; Morton Cynthia C. | Zendy

Premium

Trisomy 5 and trisomy 7 are nonrandom aberrations in pigmented villonodular synovitis: Confirmation of trisomy 7 in uncultured cells

Author(s) -

Fletcher Jonathan A.,

Henkle Carol,

Atkins Leonard,

Rosenberg Andrew E.,

Morton Cynthia C.

Publication year - 1992

Publication title -

genes, chromosomes and cancer

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.754

H-Index - 119

eISSN - 1098-2264

pISSN - 1045-2257

DOI - 10.1002/gcc.2870040312

Subject(s) - trisomy , pigmented villonodular synovitis , biology , comparative genomic hybridization , chromosome , pathology , microbiology and biotechnology , genetics , medicine , synovitis , immunology , gene , arthritis

Pigmented villonodular synovitis (PVNS) is a proliferative lesion of disputed genesis. Recently, we reported trisomy 7 in short‐term cultures of I PVNS. In the present report, we describe another specimen of PVNS in which 9 of 26 (35 percent) metaphase cells demonstrated trisomy 7 when analyzed after 3–15 days of tissue culture. In situ hybridization analysis, with a biotinylated probe to chromosome 7 alpha‐satellite DNA, revealed trisomy 7 in 53 of 200 uncultured cells from this PVNS sample. Our findings indicate that trisomy 7 is a nonrandom aberration that arises in vivo in PVNS.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research