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Trisomy 5 and trisomy 7 are nonrandom aberrations in pigmented villonodular synovitis: Confirmation of trisomy 7 in uncultured cells
Author(s) -
Fletcher Jonathan A.,
Henkle Carol,
Atkins Leonard,
Rosenberg Andrew E.,
Morton Cynthia C.
Publication year - 1992
Publication title -
genes, chromosomes and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.754
H-Index - 119
eISSN - 1098-2264
pISSN - 1045-2257
DOI - 10.1002/gcc.2870040312
Subject(s) - trisomy , pigmented villonodular synovitis , biology , comparative genomic hybridization , chromosome , pathology , microbiology and biotechnology , genetics , medicine , synovitis , immunology , gene , arthritis
Pigmented villonodular synovitis (PVNS) is a proliferative lesion of disputed genesis. Recently, we reported trisomy 7 in short‐term cultures of I PVNS. In the present report, we describe another specimen of PVNS in which 9 of 26 (35 percent) metaphase cells demonstrated trisomy 7 when analyzed after 3–15 days of tissue culture. In situ hybridization analysis, with a biotinylated probe to chromosome 7 alpha‐satellite DNA, revealed trisomy 7 in 53 of 200 uncultured cells from this PVNS sample. Our findings indicate that trisomy 7 is a nonrandom aberration that arises in vivo in PVNS.