Molecular cytogenetic analysis of a complex t(10;22;11) translocation in ewing's sarcoma
Author(s) -
Speleman Frank,
Roy Nadine Van,
Leroy Jules G.,
Dierick Anne Marie,
Uyttendaele Dirk,
Wiegant Joop
Publication year - 1992
Publication title -
genes, chromosomes and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.754
H-Index - 119
eISSN - 1098-2264
pISSN - 1045-2257
DOI - 10.1002/gcc.2870040214
Subject(s) - chromosomal translocation , fluorescence in situ hybridization , biology , sarcoma , chromosome , cytogenetics , microbiology and biotechnology , fish <actinopterygii> , molecular cytogenetics , chromosome analysis , karyotype , genetics , breakpoint , ewing's sarcoma , gene , pathology , medicine , fishery , chemotherapy
Abstract Fluorescence in situ hybridization (FISH) using chromosome‐specific plasmid libraries and chromosome region‐specific DNA markers allowed the characterization of a t(10;22;11) (p11.2;q12;q24) in a Ewing's sarcoma (ES). This study illustrates the usefulness of molecular cytogenetic analysis of ES, especially for determining the localization of the translocated 11q24–25 segment in complex or variant translocations.