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t(11;18)(q21;q21.1): A recurring translocation in lymphomas of mucosa‐associated lymphoid tissue (malt)?
Author(s) -
Horsman Douglas,
Gascoyne Randy,
Coupland Robert,
Klasa Richard
Publication year - 1992
Publication title -
genes, chromosomes and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.754
H-Index - 119
eISSN - 1098-2264
pISSN - 1045-2257
DOI - 10.1002/gcc.2870040213
Subject(s) - malt lymphoma , chromosomal translocation , lymphoma , mucosa associated lymphoid tissue , bcl10 , biology , follicular lymphoma , breakpoint , lymphatic system , pathology , chromosome 18 , cancer research , chromosome , gene , medicine , immunology , genetics
A distinct subtype of extranodal malignant lymphoma derived from mucosa‐associated lymphoid tissues (MALT) has recently been defined. We have detected an acquired t(11;18)(q21;q21.1) in a patient with a MALT lymphoma of the stomach. This translocation has previously been described in two other patients with extranodal lymphoma. The BCL2 oncogene, which is located at band 18q21.3 and is activated by the t(14;18)(q32;q21) in follicular lymphoma, was not rearranged in this case. This newly identified t(11;18) may be a recurring translocation specifically associated with MALT lymphomas. Genes located at the breakpoint sites of chromosome 11 and/or chromosome 18 may be crucial to the pathogenesis of this type of malignant lymphoma.