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Localization of the fibroblast growth factor receptor‐4 gene to chromosome region 5q33‐qter
Author(s) -
Armstrong Elina,
Partanen Juha,
Alitalo Karl,
Cannizzaro Linda,
Huebner Kay
Publication year - 1992
Publication title -
genes, chromosomes and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.754
H-Index - 119
eISSN - 1098-2264
pISSN - 1045-2257
DOI - 10.1002/gcc.2870040116
Subject(s) - fibroblast growth factor receptor 4 , fibroblast growth factor receptor 3 , fibroblast growth factor receptor 2 , biology , fibroblast growth factor receptor , receptor tyrosine kinase , cancer research , microbiology and biotechnology , chronic myelogenous leukemia , fibroblast growth factor , fgf10 , genetics , leukemia , receptor
Our polymerase chain reaction cloning of novel tyrosine kinases expressed in the K562 chronic myeloid leukemia cells has revealed a novel fibroblast growth factor receptor, FGFR4. We have here mapped the FGFR4 gene by analysis of somatic cell hybrids and in situ hybridization to the 5q33‐qter chromosomal region. This finding is of interest in that the FGFR4 gene is expressed in several leukemia cell lines and the 5q33‐qter region is involved in nonrandom chromosomal translocations in acute myelogenous leukemias and Ki‐ I lymphomas.